Reactome | NFE2L2 regulating anti-oxidant/detoxification enzymes

Schema > Pathway > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11079525
displayName	NFE2L2 regulating anti-oxidant/detoxification enzymes
eventOf	[Pathway:R-SPO-9759194] Nuclear events mediated by NFE2L2 - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SPO-5631885] PRDX1 overoxidizes - Schizosaccharomyces pombe [Reaction:R-SPO-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NFE2L2 regulating anti-oxidant/detoxification enzymes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-9818027
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SPO-9759194] Nuclear events mediated by NFE2L2
(inferredTo)	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes

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