Reactome | Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex

Schema > BlackBoxEvent > Entries

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11061718
displayName	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
eventOf	[Pathway:R-SPO-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex - Homo sapiens
input	[Complex:R-SPO-927845] mRNA Cleaved by SMG6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
output	[Complex:R-SPO-162460] Cap Binding Complex (CBC) [cytosol] [DefinedSet:R-SPO-156803-4] Homologues of PABPC1 [cytosol] [Complex:R-SPO-377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] [EntityWithAccessionedSequence:R-SPO-927867] SMG5 [cytosol] [EntityWithAccessionedSequence:R-SPO-927851] SMG6 [cytosol] [EntityWithAccessionedSequence:R-SPO-927838] SMG7 [cytosol] [EntityWithAccessionedSequence:R-SPO-72584] tif471 [cytosol] [EntityWithAccessionedSequence:R-SPO-927734] UPF1 [cytosol]
precedingEvent	[BlackBoxEvent:R-SPO-927836] SMG6 hydrolyzes mRNA with premature termination codon - Schizosaccharomyces pombe
regulatedBy	[Requirement:11061719] Requirement by 'p-4S-UPF1 [cytosol]' [Requirement:11061720] Requirement by 'PP2A (Aalpha:B55alpha:Calpha) [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-927830
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
(inferredTo)	[BlackBoxEvent:R-HSA-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex