Reactome | Assembly of the pre-replicative complex

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Assembly of the pre-replicative complex Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11078231
displayName	Assembly of the pre-replicative complex
eventOf	[Pathway:R-SPO-69002] DNA Replication Pre-Initiation - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-SPO-68962] Activation of the pre-replicative complex - Schizosaccharomyces pombe
goBiologicalProcess	[GO_BiologicalProcess:4341223] pre-replicative complex assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-SPO-68616] Assembly of the ORC complex at the origin of replication - Schizosaccharomyces pombe [Pathway:R-SPO-68689] CDC6 association with the ORC:origin complex - Schizosaccharomyces pombe [Reaction:R-SPO-9757256] MCM3 binds MCM5 - Schizosaccharomyces pombe [Reaction:R-SPO-9757257] MCM4, MCM6 and MCM7 form a heterotrimer - Schizosaccharomyces pombe [Reaction:R-SPO-9757258] MCM2 binds MCM4:MCM6:MCM7 heterotrimer - Schizosaccharomyces pombe [Reaction:R-SPO-9749253] Formation of MCM2-7 complex - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Assembly of the pre-replicative complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-68867
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-SPO-68962] Activation of the pre-replicative complex
(hasEvent)	[Pathway:R-SPO-69002] DNA Replication Pre-Initiation
(inferredTo)	[Pathway:R-HSA-68867] Assembly of the pre-replicative complex