Reactome | ULK1 phosphorylates Beclin-1

Schema > Reaction > Entries

ULK1 phosphorylates Beclin-1 Show undefined attributes

catalystActivity	[CatalystActivity:11063087] protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11067567
displayName	ULK1 phosphorylates Beclin-1
eventOf	[Pathway:R-SPO-1632852] Macroautophagy - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-5672012] Beclin-1 complex phosphorylates PtdIns - Schizosaccharomyces pombe [BlackBoxEvent:R-SPO-5682385] The phagophore extends from the PIP3-enriched structure - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-5679205] ULK1 phosphorylates Beclin-1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SPO-5683379] Beclin-1 complex [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ULK1 phosphorylates Beclin-1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SPO-5679242] ATG14:PIK3C3:PIK3R4:p-S15-BECN1 [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SPO-5679266] Beclin-1 complex translocates to the ER - Schizosaccharomyces pombe [Reaction:R-SPO-5679239] ULK complex translocates to the ER - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-5679205
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-1632852] Macroautophagy
(precedingEvent)	[Reaction:R-SPO-5672012] Beclin-1 complex phosphorylates PtdIns [BlackBoxEvent:R-SPO-5682385] The phagophore extends from the PIP3-enriched structure
(inferredTo)	[Reaction:R-HSA-5679205] ULK1 phosphorylates Beclin-1