Reactome | MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

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MSH2:MSH3 binds insertion/deletion loop of 2 bases or more Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11066531
displayName	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more
eventOf	[Pathway:R-SPO-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5358513] MSH2:MSH3 binds insertion/deletion loop of 2 bases or more - Homo sapiens
input	[OtherEntity:R-ALL-5358527] DNA containing IDL of 2 or more bases [nucleoplasm] [Complex:R-SPO-5357508] MSH2:MSH3:ADP [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MSH2:MSH3 binds insertion/deletion loop of 2 bases or more MutSbeta binds insertion/deletion loop of 2 bases or more
output	[Complex:R-SPO-5358532] MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more [nucleoplasm]
precedingEvent	[Reaction:R-SPO-5444511] Formation of MSH2:MSH3 Complex - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-5358513
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
(inferredTo)	[Reaction:R-HSA-5358513] MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

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