Reactome | SIRT1 deacetylates HSF1

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SIRT1 deacetylates HSF1 Show undefined attributes

catalystActivity	[CatalystActivity:11065065] NAD-dependent protein lysine deacetylase activity of SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11065067
displayName	SIRT1 deacetylates HSF1
eventOf	[Pathway:R-SPO-3371453] Regulation of HSF1-mediated heat shock response - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3371467] SIRT1 deacetylates HSF1 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [SimpleEntity:R-ALL-427523] NAD+ [nucleoplasm] [Complex:R-SPO-5082382] SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SIRT1 deacetylates HSF1
output	[SimpleEntity:R-ALL-427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [Complex:R-SPO-5082415] HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] [SimpleEntity:R-ALL-427497] NAM [nucleoplasm] [EntityWithAccessionedSequence:R-SPO-427531] SIRT1 [nucleoplasm]
precedingEvent	[Reaction:R-SPO-3371518] SIRT1 binds to HSF1 - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-3371467
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-3371453] Regulation of HSF1-mediated heat shock response
(inferredTo)	[Reaction:R-HSA-3371467] SIRT1 deacetylates HSF1