Reactome | COQ3 methylates DHDB

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COQ3 methylates DHDB Show undefined attributes

catalystActivity	[CatalystActivity:11063840] polyprenyldihydroxybenzoate methyltransferase activity of COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11063842
displayName	COQ3 methylates DHDB
eventOf	[Pathway:R-SPO-2142789] Ubiquinol biosynthesis - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-2162195] COQ4 decarboxylates MHDB - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-2162193] COQ3 methylates DHDB - Homo sapiens
input	[SimpleEntity:R-ALL-2162265] AdoMet [mitochondrial matrix] [SimpleEntity:R-ALL-2162209] DHDB [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	COQ3 methylates DHDB DHDB is methylated to MHDB by COQ3
output	[SimpleEntity:R-ALL-2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-2162215] MHDB [mitochondrial inner membrane]
precedingEvent	[Reaction:R-SPO-2162187] COQ6 hydroxylates DHB - Schizosaccharomyces pombe [Reaction:R-SPO-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-2162193
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-2142789] Ubiquinol biosynthesis
(precedingEvent)	[Reaction:R-SPO-2162195] COQ4 decarboxylates MHDB
(inferredTo)	[Reaction:R-HSA-2162193] COQ3 methylates DHDB