Reactome | SLC25A32 transports THF from cytosol to mitochondrial matrix

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SLC25A32 transports THF from cytosol to mitochondrial matrix Show undefined attributes

catalystActivity	[CatalystActivity:11058331] folic acid transmembrane transporter activity of SLC25A32 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11058333
displayName	SLC25A32 transports THF from cytosol to mitochondrial matrix
eventOf	[Pathway:R-SPO-196757] Metabolism of folate and pterines - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Homo sapiens
input	[SimpleEntity:R-ALL-111355] THF [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A32 transports THF from cytosol to mitochondrial matrix Cytosolic tetrahydrofolate import across the inner mitochondrial membrane
output	[SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
precedingEvent	[Reaction:R-SPO-197972] DHF is reduced to tetrahydrofolate (THF) - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-200680
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-SPO-200682] Mitochondrial FPGS-1 transforms THF to THFPG
(inferredTo)	[Reaction:R-HSA-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix

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