Reactome | POLD,POLE-mediated DNA strand displacement synthesis

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POLD,POLE-mediated DNA strand displacement synthesis Show undefined attributes

catalystActivity	[CatalystActivity:11055671] DNA-directed DNA polymerase activity of APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11055673
displayName	POLD,POLE-mediated DNA strand displacement synthesis
eventOf	[Pathway:R-SPO-5651801] PCNA-Dependent Long Patch Base Excision Repair - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-110368] POLD,POLE-mediated DNA strand displacement synthesis - Homo sapiens
input	[Complex:R-SPO-110407] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] 10 × [SimpleEntity:R-ALL-30555] dNTP [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLD,POLE-mediated DNA strand displacement synthesis
output	[Complex:R-SPO-5651812] APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] 10 × [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-110368
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-5651801] PCNA-Dependent Long Patch Base Excision Repair
(inferredTo)	[Reaction:R-HSA-110368] POLD,POLE-mediated DNA strand displacement synthesis

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