Reactome | ERCC1:ERCC4 [nucleoplasm]

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ERCC1:ERCC4 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-SPO-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SPO-6782142] TC-NER incision complex [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SPO-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SPO-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] - Schizosaccharomyces pombe
consumedByEvent	[Reaction:R-SPO-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER - Schizosaccharomyces pombe [Reaction:R-SPO-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Schizosaccharomyces pombe
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11055448
displayName	ERCC1:ERCC4 [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-SPO-67445] rad16 [nucleoplasm] [EntityWithAccessionedSequence:R-SPO-54427] swi10 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-109943] ERCC1:ERCC4 [nucleoplasm] - Homo sapiens
maxDepth	2
name	ERCC1:ERCC4
producedByEvent	[Reaction:R-SPO-6782224] 3' incision by ERCC5 (XPG) in TC-NER - Schizosaccharomyces pombe [Reaction:R-SPO-109955] Formation of ERCC1:XPF heterodimeric complex - Schizosaccharomyces pombe
schemaClass	Complex
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-109943
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-SPO-6782224] 3' incision by ERCC5 (XPG) in TC-NER [Reaction:R-SPO-109955] Formation of ERCC1:XPF heterodimeric complex
(hasComponent)	[Complex:R-SPO-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-SPO-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-SPO-6782142] TC-NER incision complex [nucleoplasm] [Complex:R-SPO-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-SPO-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-SPO-5691046] GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
(activeUnit)	[CatalystActivity:11069006] DNA endonuclease activity of TC-NER incision complex [nucleoplasm] [CatalystActivity:11068168] endonuclease activity of GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
(input)	[Reaction:R-SPO-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER [Reaction:R-SPO-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
(inferredTo)	[Complex:R-HSA-109943] ERCC1:ERCC4 [nucleoplasm]

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