Reactome | TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol

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TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol Show undefined attributes

catalystActivity	[CatalystActivity:11085939] Delta14-sterol reductase activity of TM7SF2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11106471
displayName	TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol
eventOf	[Pathway:R-SCE-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9946140] TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol - Homo sapiens
input	[SimpleEntity:R-ALL-9946142] 4,4-diMe-8,14-cholestadien-3b-ol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol 4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H(+) => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)
output	[SimpleEntity:R-ALL-9946141] 4,4-diMe-5-cholest-8-en-3-ol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9946140
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
(inferredTo)	[Reaction:R-HSA-9946140] TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol

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