Reactome | DHRSX reduces dolichal to dolichol

Schema > Reaction > Entries

DHRSX reduces dolichal to dolichol Show undefined attributes

catalystActivity	[CatalystActivity:11106409] alcohol dehydrogenase (NADP+) activity of DHRSX [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:171062] early endosome membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11106411
displayName	DHRSX reduces dolichal to dolichol
eventOf	[Pathway:R-SCE-446199] Synthesis of dolichyl-phosphate - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-446195] DOLK phosphorylates DCHOL to DOLP - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-9937340] DHRSX reduces dolichal to dolichol - Homo sapiens
input	[SimpleEntity:R-ALL-9937289] DCHAL [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DHRSX reduces dolichal to dolichol a di-trans,poly-cis-dolichal + NADPH + H(+) => a di-trans,poly-cis-dolichol + NADP(+)
output	[SimpleEntity:R-ALL-449221] DCHOL [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-SCE-9937295] SRD5A3 reduces polyprenal to dolichal - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9937340
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-446199] Synthesis of dolichyl-phosphate
(precedingEvent)	[Reaction:R-SCE-446195] DOLK phosphorylates DCHOL to DOLP
(inferredTo)	[Reaction:R-HSA-9937340] DHRSX reduces dolichal to dolichol

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