Reactome | Mitochondrial protein degradation

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Mitochondrial protein degradation Show undefined attributes

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11108268
displayName	Mitochondrial protein degradation
eventOf	[TopLevelPathway:R-SCE-392499] Metabolism of proteins - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1301039] mitochondrial protein catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SCE-9838321] PRKACA phosphorylates TFAM in the mitochondrial matrix - Saccharomyces cerevisiae [Reaction:R-SCE-9838093] LONP1 binds mitochondrial matrix proteins - Saccharomyces cerevisiae [BlackBoxEvent:R-SCE-9838081] LONP1 degrades mitochondrial matrix proteins - Saccharomyces cerevisiae [Reaction:R-SCE-9837978] LONP1 binds mitochondrial inner membrane proteins - Saccharomyces cerevisiae [BlackBoxEvent:R-SCE-9838004] LONP1 degrades mitochondrial inner membrane proteins - Saccharomyces cerevisiae [Reaction:R-SCE-9839149] AFG3L2 binds mitochondrial matrix proteins - Saccharomyces cerevisiae [BlackBoxEvent:R-SCE-9839105] AFG3L2 degrades mitochondrial matrix proteins - Saccharomyces cerevisiae [Reaction:R-SCE-9838627] AFG3L2 binds mitochondrial inner membrane proteins - Saccharomyces cerevisiae [BlackBoxEvent:R-SCE-9839113] AFG3L2 degrades mitochondrial inner membrane proteins - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-9837999] Mitochondrial protein degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Mitochondrial protein degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-9837999
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-SCE-392499] Metabolism of proteins
(inferredTo)	[Pathway:R-HSA-9837999] Mitochondrial protein degradation

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