Reactome | SLC46A1 transports hemes from extracellular region to cytosol

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SLC46A1 transports hemes from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:11090219] heme transmembrane transporter activity of SLC46A1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11090221
displayName	SLC46A1 transports hemes from extracellular region to cytosol
eventOf	[Pathway:R-SCE-9707616] Heme signaling - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-917870] SLC46A1 transports hemes from extracellular region to cytosol - Homo sapiens
input	[CandidateSet:R-ALL-9707310] Hemes [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC46A1 transports hemes from extracellular region to cytosol Extracellular ferriheme uptake through the apical membrane of enterocytes
output	[CandidateSet:R-ALL-9707308] Hemes [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-917870
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-9707616] Heme signaling [Pathway:R-SCE-917937] Iron uptake and transport
(inferredTo)	[Reaction:R-HSA-917870] SLC46A1 transports hemes from extracellular region to cytosol

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