Reactome | GABA synthesis, release, reuptake and degradation

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GABA synthesis, release, reuptake and degradation Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:917758] clathrin-sculpted gamma-aminobutyric acid transport vesicle
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107582
displayName	GABA synthesis, release, reuptake and degradation
eventOf	[Pathway:R-SCE-112310] Neurotransmitter release cycle - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SCE-888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen - Saccharomyces cerevisiae [Pathway:R-SCE-916853] Degradation of GABA - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-888590] GABA synthesis, release, reuptake and degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	GABA synthesis, release, reuptake and degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-888590
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-112310] Neurotransmitter release cycle
(inferredTo)	[Pathway:R-HSA-888590] GABA synthesis, release, reuptake and degradation

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