Reactome | CHOL translocates from lysosome membrane to ER membrane

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CHOL translocates from lysosome membrane to ER membrane Show undefined attributes

category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17938] lysosomal membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11102703
displayName	CHOL translocates from lysosome membrane to ER membrane
eventOf	[Pathway:R-SCE-8964038] LDL clearance - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8876485] CHOL translocates from lysosome membrane to ER membrane - Homo sapiens
input	[Complex:R-SCE-8876475] NPC1:CHOL [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CHOL translocates from lysosome membrane to ER membrane
output	[SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-SCE-5216153] NCR1 [lysosomal membrane]
precedingEvent	[Reaction:R-SCE-8876484] NPC2 transfers CHOL to NPC1 - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-8876485
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-8964038] LDL clearance
(inferredTo)	[BlackBoxEvent:R-HSA-8876485] CHOL translocates from lysosome membrane to ER membrane

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