Reactome | OMA1 hydrolyses OPA1

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OMA1 hydrolyses OPA1 Show undefined attributes

catalystActivity	[CatalystActivity:11102156] metalloendopeptidase activity of OMA1:Zn2+ [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11102158
displayName	OMA1 hydrolyses OPA1
eventOf	[Pathway:R-SCE-169911] Regulation of Apoptosis - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8867344] OMA1 hydrolyses OPA1 - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [DefinedSet:R-SCE-8867508-3] Homologues of OPA1 [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	OMA1 hydrolyses OPA1
output	[DefinedSet:R-SCE-8867513-3] Homologues of OPA1(195-960) [mitochondrial inner membrane] [DefinedSet:R-SCE-8867509-3] Homologues of OPA1(88-194) [mitochondrial inner membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-8867344
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-169911] Regulation of Apoptosis
(inferredTo)	[Reaction:R-HSA-8867344] OMA1 hydrolyses OPA1