Reactome | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

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PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Show undefined attributes

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107684
displayName	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
eventOf	[Pathway:R-SCE-199418] Negative regulation of the PI3K/AKT network - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262291] regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SCE-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SCE-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SCE-6811504] AKT1 dephosphorylation by PP2A-B56-beta,gamma - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-6811558
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-199418] Negative regulation of the PI3K/AKT network
(inferredTo)	[Pathway:R-HSA-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

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