Reactome | Active RNA Pol II complex transcribes lesion-containing DNA template

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Active RNA Pol II complex transcribes lesion-containing DNA template Show undefined attributes

catalystActivity	[CatalystActivity:11097732] DNA-directed RNA polymerase activity of Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11097734
displayName	Active RNA Pol II complex transcribes lesion-containing DNA template
eventOf	[Pathway:R-SCE-6781823] Formation of TC-NER Pre-Incision Complex - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-6781840] ERCC6 binds stalled RNA Pol II - Saccharomyces cerevisiae
inferredFrom	[BlackBoxEvent:R-HSA-6781824] Active RNA Pol II complex transcribes lesion-containing DNA template - Homo sapiens
input	[Complex:R-SCE-6781821] Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] [SimpleEntity:R-ALL-6781829] ribonucleoside triphosphate [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Active RNA Pol II complex transcribes lesion-containing DNA template
output	[Complex:R-SCE-6781822] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-SCE-6781818] RNA Pol II initiates transcription from damaged DNA template - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-6781824
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-6781823] Formation of TC-NER Pre-Incision Complex
(precedingEvent)	[Reaction:R-SCE-6781840] ERCC6 binds stalled RNA Pol II
(inferredTo)	[BlackBoxEvent:R-HSA-6781824] Active RNA Pol II complex transcribes lesion-containing DNA template

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