Reactome | AMT transfers NH2CH2 from GCSH:SAMDLL to THF

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AMT transfers NH2CH2 from GCSH:SAMDLL to THF Show undefined attributes

catalystActivity	[CatalystActivity:11097216] aminomethyltransferase activity of AMT [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11097218
displayName	AMT transfers NH2CH2 from GCSH:SAMDLL to THF
eventOf	[Pathway:R-SCE-6783984] Glycine degradation - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF - Homo sapiens
input	[Complex:R-SCE-5693969] AmMeLipoGCSH:SAMDLL [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	AMT transfers NH2CH2 from GCSH:SAMDLL to THF (6S)-5,6,7,8-tetrahydrofolate + N(6)-((R)-S(8)-aminomethyldihydrolipoyl)-L-lysyl-(protein) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-((R)-dihydrolipoyl)-L-lysyl-(protein) + NH4(+) AMT degrades GCSH:SAMDLL to GCSH:DHLL
output	[SimpleEntity:R-ALL-5693984] 5,10-methylene-THF [mitochondrial matrix] [Complex:R-SCE-5693982] GCSH:DHLL [mitochondrial matrix] [SimpleEntity:R-ALL-113561] NH4+ [mitochondrial matrix]
precedingEvent	[Reaction:R-SCE-5693967] PXLP-K754-GLDC dimer decarboxylates Gly - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-5693977
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-6783984] Glycine degradation
(precedingEvent)	[Reaction:R-SCE-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate
(inferredTo)	[Reaction:R-HSA-5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF

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