Reactome | LC3 de-lipidation by ATG4

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LC3 de-lipidation by ATG4 Show undefined attributes

catalystActivity	[CatalystActivity:11096506] cysteine-type endopeptidase activity of ATG4 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:5679192] phagophore assembly site membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11096573
displayName	LC3 de-lipidation by ATG4
eventOf	[Pathway:R-SCE-1632852] Macroautophagy - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SCE-5682011] LC3 binds ATG7 dimer - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-5682377] LC3 de-lipidation by ATG4 - Homo sapiens
input	[Complex:R-SCE-5682873] LC3:PE [phagophore assembly site membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	LC3 de-lipidation by ATG4
output	[EntityWithAccessionedSequence:R-SCE-5205676] ATG8 [cytosol] [SimpleEntity:R-ALL-5681998] PE [phagophore assembly site membrane]
precedingEvent	[Reaction:R-SCE-5678490] ATG16L1 complex transfers LC3 from ATG3 to PE - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-5682377
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-1632852] Macroautophagy
(precedingEvent)	[BlackBoxEvent:R-SCE-5682011] LC3 binds ATG7 dimer
(inferredTo)	[Reaction:R-HSA-5682377] LC3 de-lipidation by ATG4

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