Reactome | GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P

Schema > Reaction > Entries

GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P Show undefined attributes

catalystActivity	[CatalystActivity:11089420] glutamine-fructose-6-phosphate transaminase (isomerizing) activity of GFPT1,2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11089422
displayName	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P
eventOf	[Pathway:R-SCE-446210] Synthesis of UDP-N-acetyl-glucosamine - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-449734] Acetylation of glucosamine 6-phosphate to GlcNAc6P - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P - Homo sapiens
input	[SimpleEntity:R-ALL-29512] Fru(6)P [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate Formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine
output	[SimpleEntity:R-ALL-449701] GlcN6P [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
precedingEvent	[Reaction:R-SCE-70471] GPI dimer isomerizes G6P - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-449715
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-446210] Synthesis of UDP-N-acetyl-glucosamine
(precedingEvent)	[Reaction:R-SCE-449734] Acetylation of glucosamine 6-phosphate to GlcNAc6P
(inferredTo)	[Reaction:R-HSA-449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P

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