Reactome | Cation-coupled Chloride cotransporters

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Cation-coupled Chloride cotransporters Show undefined attributes

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107490
displayName	Cation-coupled Chloride cotransporters
eventOf	[Pathway:R-SCE-9958790] SLC-mediated transport of inorganic anions - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5083557] chloride transmembrane transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SCE-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Saccharomyces cerevisiae [Reaction:R-SCE-9725706] SLC12A3 binds SLC12A3 inhibitors - Saccharomyces cerevisiae [Reaction:R-SCE-426086] SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-426117] Cation-coupled Chloride cotransporters - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Cation-coupled Chloride cotransporters
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-426117
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-9958790] SLC-mediated transport of inorganic anions
(inferredTo)	[Pathway:R-HSA-426117] Cation-coupled Chloride cotransporters

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