Reactome | Unfolded Protein Response (UPR)

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Unfolded Protein Response (UPR) Show undefined attributes

compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107406
displayName	Unfolded Protein Response (UPR)
eventOf	[Pathway:R-SCE-2262752] Cellular responses to stress - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:161539] endoplasmic reticulum unfolded protein response
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-SCE-381070] IRE1alpha activates chaperones - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-381119] Unfolded Protein Response (UPR) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Unfolded Protein Response (UPR)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-381119
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-2262752] Cellular responses to stress
(inferredTo)	[Pathway:R-HSA-381119] Unfolded Protein Response (UPR)

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