Reactome | LTA4 is hydolysed to LTB4 by LTA4H

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LTA4 is hydolysed to LTB4 by LTA4H Show undefined attributes

catalystActivity	[CatalystActivity:11087362] leukotriene-A4 hydrolase activity of LTA4H:Zn2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11087364
displayName	LTA4 is hydolysed to LTB4 by LTA4H
eventOf	[Pathway:R-SCE-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-266072] LTA4 is hydolysed to LTB4 by LTA4H - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-265281] LTA4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LTA4 is hydolysed to LTB4 by LTA4H H2O + leukotriene A4 => leukotriene B4 LTA4 is hydrolyzed to LTB4
output	[SimpleEntity:R-ALL-266056] LTB4 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-266072
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(inferredTo)	[Reaction:R-HSA-266072] LTA4 is hydolysed to LTB4 by LTA4H

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