Reactome | SMPD1 hydrolyzes SPHM

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SMPD1 hydrolyzes SPHM Show undefined attributes

catalystActivity	[CatalystActivity:11091892] sphingomyelin phosphodiesterase activity of SMPD1 [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11091894
displayName	SMPD1 hydrolyzes SPHM
eventOf	[Pathway:R-SCE-9840310] Glycosphingolipid catabolism - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1605797] SMPD1 hydrolyzes SPHM - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-1605713] SPHM d18:1 [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	SMPD1 hydrolyzes SPHM
output	[SimpleEntity:R-ALL-1605673] CERA [lysosomal lumen] [SimpleEntity:R-ALL-1605750] ChoP [lysosomal lumen] [SimpleEntity:R-ALL-428040] H+ [lysosomal lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-1605797
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-9840310] Glycosphingolipid catabolism
(inferredTo)	[Reaction:R-HSA-1605797] SMPD1 hydrolyzes SPHM