Reactome | MPP hydrolyzes presequence of inner membrane precursors

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MPP hydrolyzes presequence of inner membrane precursors Show undefined attributes

authored	[InstanceEdit:1258402] May, B, 2011-05-03
catalystActivity	[CatalystActivity:1268016] metalloendopeptidase activity of Mitochondrial processing peptidase [mitochondrial matrix]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1268018] May, B, 2011-05-09
dbId	1268019
deleted	[Deleted:9697205] Deletion of instance: 1252265
displayName	MPP hydrolyzes presequence of inner membrane precursors
edited	[InstanceEdit:1258402] May, B, 2011-05-03
followingEvent	[Reaction:R-SCE-1252249] TIM23 SORT complex inserts proteins into inner membrane - Saccharomyces cerevisiae
input	[Complex:R-SCE-1268007] TIM23 SORT:Precursor Cargo [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1267950] The MAS-encoded processing protease of yeast mitochondria. Interaction of the purified enzyme with signal peptides and a purified precursor protein [LiteratureReference:1267928] Functional reconstitution in Escherichia coli of the yeast mitochondrial matrix peptidase from its two inactive subunits [LiteratureReference:1267943] Functional cooperation of the mitochondrial processing peptidase subunits [LiteratureReference:1267929] The mitochondrial processing peptidase behaves as a zinc-metallopeptidase [LiteratureReference:1267951] Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences [LiteratureReference:1267931] Glycine-rich loop of mitochondrial processing peptidase alpha-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MPP hydrolyzes presequence of inner membrane precursors
orthologousEvent	[Reaction:R-HSA-1299476] MPP cleaves targeting peptide (presequence) of inner membrane precursors - Homo sapiens
output	[Complex:R-SCE-1268011] TIM23 SORT:Cargo [mitochondrial inner membrane]
precedingEvent	[Reaction:R-SCE-1268015] Precursor proteins enter TIM23 SORT complex - Saccharomyces cerevisiae
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:2108993] Endo, T, 2012-02-12
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-1268019
summation	[Summation:1267884] The alpha subunit (MAS2, Alpha-MPP) of the mitochondrial pro...

Referrals

(replacementInstances)	[Deleted:9697205] Deletion of instance: 1252265
(precedingEvent)	[Reaction:R-SCE-1252249] TIM23 SORT complex inserts proteins into inner membrane

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