Reactome | GSK3B phosphorylates CD274

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GSK3B phosphorylates CD274 Show undefined attributes

catalystActivity	[CatalystActivity:10219928] protein serine/threonine kinase activity of GSK3B [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10219939
displayName	GSK3B phosphorylates CD274
eventOf	[Pathway:R-RNO-9929356] GSK3B-mediated proteasomal degradation of PD-L1(CD274) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9931419] Transport of p-S184,T180-CD274 to cytosol - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9929360] GSK3B phosphorylates CD274 - Homo sapiens
input	[SimpleEntity:R-ALL-8931885] ATP [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-RNO-9930703] Cd274 [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GSK3B phosphorylates CD274
output	[SimpleEntity:R-ALL-8931884] ADP [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-RNO-9929349] phospho-Cd274 [endoplasmic reticulum membrane]
regulatedBy	[NegativeRegulation:10219940] Negative regulation by 'N-glycosylated CD274 [endoplasmic reticulum membrane]' [NegativeRegulation:10219941] Negative regulation by 'p-T194,T210-CD274 [endoplasmic reticulum membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9929360
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9929356] GSK3B-mediated proteasomal degradation of PD-L1(CD274)
(precedingEvent)	[BlackBoxEvent:R-RNO-9931419] Transport of p-S184,T180-CD274 to cytosol
(inferredTo)	[Reaction:R-HSA-9929360] GSK3B phosphorylates CD274