Reactome | TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst)

Schema > Reaction > Entries

TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10216683] serine-type endopeptidase activity of TF:FVIIa [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10219897
displayName	TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst)
eventOf	[Pathway:R-RNO-9769735] Initiation of coagulation cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9929054] TF:FVIIa:FIXa ->TF:FVIIa + FIXa - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9929051] TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst) - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-140886] 12xCbxE-3D-F9(47-461) [extracellular region] [Complex:R-RNO-140734] TF:FVIIa [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst) TF:FVIIa converts FX to FXa activation of factor X by TF:FVIIa
output	[EntityWithAccessionedSequence:R-RNO-140897] factor IX activation peptide [extracellular region] [Complex:R-RNO-9929061] TF:FVIIa:FIXa [plasma membrane]
precedingEvent	[Reaction:R-RNO-140748] tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex - Rattus norvegicus [Reaction:R-RNO-9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa - Rattus norvegicus [BlackBoxEvent:R-RNO-9670673] FIX is secreted - Rattus norvegicus
regulatedBy	[PositiveRegulation:R-HSA-158645] Positive regulation by 'Ca2+ [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9929051
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-RNO-9929054] TF:FVIIa:FIXa ->TF:FVIIa + FIXa
(inferredTo)	[Reaction:R-HSA-9929051] TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst)

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