Reactome | Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species

Schema > BlackBoxEvent > Entries

Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10217673
displayName	Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species
eventOf	[Pathway:R-RNO-9841251] Mitochondrial unfolded protein response (UPRmt) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9841265] p-S473-AKT1 phosphorylates ESR1 on serine-167 - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-9841244] Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-437274] Akt1 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-9841264] phospho-p-S473-AKT1 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9841244
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9841251] Mitochondrial unfolded protein response (UPRmt)
(precedingEvent)	[Reaction:R-RNO-9841265] p-S473-AKT1 phosphorylates ESR1 on serine-167
(inferredTo)	[BlackBoxEvent:R-HSA-9841244] Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species

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