Reactome | bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer

Schema > Reaction > Entries

bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer Show undefined attributes

catalystActivity	[CatalystActivity:10156901] beta-N-acetylhexosaminidase activity of bHEXA,bHEXB [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10217654
displayName	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer
eventOf	[Pathway:R-RNO-9840310] Glycosphingolipid catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1606312] GLB1 hydrolyzes SapB/C:LacCer - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9840833] bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer - Homo sapiens
input	[Complex:R-RNO-9840792] GM2A:GA2 [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer
output	[SimpleEntity:R-ALL-1605658] GalNAc [lysosomal lumen] [Complex:R-RNO-9840837] GM2A:LacCer [lysosomal lumen]
precedingEvent	[Reaction:R-RNO-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9840833
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-RNO-1606312] GLB1 hydrolyzes SapB/C:LacCer
(inferredTo)	[Reaction:R-HSA-9840833] bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer

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