Reactome | TGFBR3_mem cleavage by MMPs

Schema > Reaction > Entries

TGFBR3_mem cleavage by MMPs Show undefined attributes

catalystActivity	[CatalystActivity:10156732] serine-type endopeptidase activity of MMP14 (16) [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10217561
displayName	TGFBR3_mem cleavage by MMPs
eventOf	[Pathway:R-RNO-9839383] TGFBR3 PTM regulation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9839368] TGFBR3(1-783) binds to TGFB1,TGFB2 - Rattus norvegicus [BlackBoxEvent:R-RNO-9839376] TGFBR3(784-851) degradation - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9839367] TGFBR3_mem cleavage by MMPs - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-9839336] Tgfbr3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TGFBR3_mem cleavage by MMPs
output	[EntityWithAccessionedSequence:R-RNO-9839380] Tgfbr3 [basolateral plasma membrane] [EntityWithAccessionedSequence:R-RNO-9839335] Tgfbr3 [extracellular region]
precedingEvent	[BlackBoxEvent:R-RNO-9839388] TGFBR3 translocation to plasma membrane - Rattus norvegicus
regulatedBy	[NegativeRegulation:10217562] Negative regulation by 'TIMP1 [extracellular region]' [NegativeRegulation:10217563] Negative regulation by 'TIMP2 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9839367
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-9839368] TGFBR3(1-783) binds to TGFB1,TGFB2 [BlackBoxEvent:R-RNO-9839376] TGFBR3(784-851) degradation
(hasEvent)	[Pathway:R-RNO-9839383] TGFBR3 PTM regulation
(inferredTo)	[Reaction:R-HSA-9839367] TGFBR3_mem cleavage by MMPs