Reactome | Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7

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Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7 Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225417
displayName	Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7
eventOf	[Pathway:R-RNO-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-RNO-9823939] IKK? (IKBKE) is ubiquitinated within the activated TLR4 - Rattus norvegicus [BlackBoxEvent:R-RNO-9823904] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Rattus norvegicus [Reaction:R-RNO-9823934] OPTN binds TBK1 within the activated TLR4 complex - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9824878
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(inferredTo)	[Pathway:R-HSA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7

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