Reactome | ULK1 phosphorylates RIPK1 at S357

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ULK1 phosphorylates RIPK1 at S357 Show undefined attributes

catalystActivity	[CatalystActivity:10216592] protein serine/threonine kinase activity of ULK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10216594
displayName	ULK1 phosphorylates RIPK1 at S357
eventOf	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9819106] ULK1 phosphorylates RIPK1 at S357 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-140935] TRAF2:TRADD:RIPK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ULK1 phosphorylates RIPK1 at S357
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-9819071] TRAF2:TRADD:p-S357-RIPK1 [cytosol]
precedingEvent	[Reaction:R-RNO-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9819106
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-9819106] ULK1 phosphorylates RIPK1 at S357

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