Reactome | MIB2 ubiquitinates CFLAR

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MIB2 ubiquitinates CFLAR Show undefined attributes

catalystActivity	[CatalystActivity:10216366] ubiquitin-protein transferase activity of CFLAR:MIB2:Ub:UBE2D1 [cytosol]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10216368
displayName	MIB2 ubiquitinates CFLAR
eventOf	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9796626] MIB2 ubiquitinates CFLAR - Homo sapiens
input	[Complex:R-RNO-9796628] CFLAR:MIB2:Ub:UBE2D1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MIB2 ubiquitinates CFLAR
output	[EntityWithAccessionedSequence:R-RNO-9818805] Cflar [cytosol] [EntityWithAccessionedSequence:R-RNO-1472879] MIB2 [cytosol] [EntityWithAccessionedSequence:R-RNO-8864160] Ube2d1 [cytosol]
precedingEvent	[Reaction:R-RNO-9796617] MIB2 binds CFLAR - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9796626
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-9796626] MIB2 ubiquitinates CFLAR