Reactome | Histidine is decarboxylated to histamine

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Histidine is decarboxylated to histamine Show undefined attributes

catalystActivity	[CatalystActivity:10148036] histidine decarboxylase activity of PXLP-K305-HDC dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10148038
displayName	Histidine is decarboxylated to histamine
eventOf	[Pathway:R-RNO-70921] Histidine catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:654] histamine biosynthetic process
inferredFrom	[Reaction:R-HSA-977301] Histidine is decarboxylated to histamine - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29612] L-His [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Histidine is decarboxylated to histamine H(+) + L-histidine => CO2 + histamine
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-175992] Hist [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-977301
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-70921] Histidine catabolism
(inferredTo)	[Reaction:R-HSA-977301] Histidine is decarboxylated to histamine

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