Reactome | Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation

Schema > Reaction > Entries

Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10215151
displayName	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
eventOf	[Pathway:R-RNO-9755511] KEAP1-NFE2L2 pathway - Rattus norvegicus [Pathway:R-RNO-8951664] Neddylation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-8932355] 26S proteasome degrades Ub-NFE2L2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9758090] Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation - Homo sapiens
input	[Complex:R-RNO-9755501] ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
output	2 × [Complex:R-RNO-8932333] KEAP1:NEDD8-CUL3:RBX1 [cytosol] [EntityWithAccessionedSequence:R-RNO-9758077] Nfe2l2 [cytosol] [Complex:R-RNO-9755500] UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol]
precedingEvent	[Reaction:R-RNO-9755507] UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9758090
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8951664] Neddylation [Pathway:R-RNO-9755511] KEAP1-NFE2L2 pathway
(precedingEvent)	[BlackBoxEvent:R-RNO-8932355] 26S proteasome degrades Ub-NFE2L2
(inferredTo)	[Reaction:R-HSA-9758090] Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation

Cite Us!