Reactome | GMPS dimer transforms 6TXMP to 6TGMP

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GMPS dimer transforms 6TXMP to 6TGMP Show undefined attributes

catalystActivity	[CatalystActivity:10214828] GMP synthase (glutamine-hydrolyzing) activity of GMPS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10214830
displayName	GMPS dimer transforms 6TXMP to 6TGMP
eventOf	[Pathway:R-RNO-9748787] Azathioprine ADME - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Rattus norvegicus [Reaction:R-RNO-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region - Rattus norvegicus [Reaction:R-RNO-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9748957] GMPS dimer transforms 6TXMP to 6TGMP - Homo sapiens
input	[SimpleEntity:R-ALL-9748959] 6TXMP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GMPS dimer transforms 6TXMP to 6TGMP 6TXMP--GMPS-->6TGMP
output	[SimpleEntity:R-ALL-9748970] 6TGMP [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-RNO-9748945] IMPDH tetramers dehydrogenate 6TIMP to 6TXMP - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9748957
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9748787] Azathioprine ADME
(precedingEvent)	[Reaction:R-RNO-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region [Reaction:R-RNO-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region [Reaction:R-RNO-9748949] GUK1 phosphorylates 6TGMP to 6TGDP
(inferredTo)	[Reaction:R-HSA-9748957] GMPS dimer transforms 6TXMP to 6TGMP