Reactome | Drug-mediated inhibition of MET activation

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225365
displayName	Drug-mediated inhibition of MET activation
eventOf	[Pathway:R-RNO-6807004] Negative regulation of MET activity - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9734070] Anti-MET recombinant therapeutic antibodies bind MET - Rattus norvegicus [Reaction:R-RNO-9735946] Anti-MET small tyrosine kinase inhibitors bind MET - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9734091] Drug-mediated inhibition of MET activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Drug-mediated inhibition of MET activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9734091
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-6807004] Negative regulation of MET activity
(inferredTo)	[Pathway:R-HSA-9734091] Drug-mediated inhibition of MET activation

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