Reactome | PTPN6 dephosphorylates JAK3

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PTPN6 dephosphorylates JAK3 Show undefined attributes

catalystActivity	[CatalystActivity:10150679] protein tyrosine phosphatase activity of PTPN6 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10213422
displayName	PTPN6 dephosphorylates JAK3
eventOf	[Pathway:R-RNO-201556] Signaling by ALK - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9701507] PTPN6 dephosphorylates JAK3 - Homo sapiens
input	[Complex:R-RNO-9701475] Active ALK:p-Y980 JAK3 [plasma membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPN6 dephosphorylates JAK3
output	[Complex:R-RNO-9701478] Active ALK:JAK3 [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-RNO-9701488] Active ALK phosphorylates JAK3 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9701507
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-201556] Signaling by ALK
(inferredTo)	[Reaction:R-HSA-9701507] PTPN6 dephosphorylates JAK3

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