Reactome | RAS proteins are depalmitoylated

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RAS proteins are depalmitoylated Show undefined attributes

catalystActivity	[CatalystActivity:10212198] palmitoyl-(protein) hydrolase activity of LYPLA1 dimer, ABHD17A,B,C [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10212200
displayName	RAS proteins are depalmitoylated
eventOf	[Pathway:R-RNO-9648002] RAS processing - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9647994] RAS proteins are depalmitoylated - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-RNO-9647962] S-Farn-Me-PalmS KRAS4A, HRAS, NRAS [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RAS proteins are depalmitoylated
output	[SimpleEntity:R-ALL-8848337] PALM(-) [cytosol] [DefinedSet:R-RNO-9647970] S-Farn-Me KRAS4A, HRAS, NRAS [plasma membrane]
precedingEvent	[BlackBoxEvent:R-RNO-9647980] mature RAS proteins translocate to plasma membrane - Rattus norvegicus
regulatedBy	[NegativeRegulation:10212201] Negative regulation by 'Palmostatin B:LYPLA1 dimer, ABHD17A,B,C [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9647994
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9648002] RAS processing
(inferredTo)	[Reaction:R-HSA-9647994] RAS proteins are depalmitoylated

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