Reactome | PolyUb-Misfolded proteins bind vimentin to form aggresome

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PolyUb-Misfolded proteins bind vimentin to form aggresome Show undefined attributes

category	binding
compartment	[Compartment:18667] microtubule organizing center
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10212027
displayName	PolyUb-Misfolded proteins bind vimentin to form aggresome
eventOf	[Pathway:R-RNO-9646399] Aggrephagy - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9646685] Aggresome dissociates from dynein and microtubule - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9646679] PolyUb-Misfolded proteins bind vimentin to form aggresome - Homo sapiens
input	[Polymer:R-RNO-9657899] Poly-vimentin [microtubule organizing center] [Complex:R-RNO-9646389] PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center]
isInDisease	false
isInferred	true
maxDepth	1
name	PolyUb-Misfolded proteins bind vimentin to form aggresome
output	[Complex:R-RNO-9646684] Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9646679
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9646399] Aggrephagy
(precedingEvent)	[Reaction:R-RNO-9646685] Aggresome dissociates from dynein and microtubule
(inferredTo)	[Reaction:R-HSA-9646679] PolyUb-Misfolded proteins bind vimentin to form aggresome

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