Reactome | Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-9691431] BTK:BTK inhibitors [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9691421] BTK binds BTK inhibitors - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10210723
displayName	Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane]
hasComponent	[Complex:R-RNO-983687] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] [Complex:R-RNO-9606157] BTK:PIP3 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-197954] Nck1 [cytosol] [Complex:R-RNO-9606170] PLCG2:PIP3 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-195066] Vav1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9606167] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] - Homo sapiens
maxDepth	12
name	Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2
producedByEvent	[Reaction:R-RNO-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9606167
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-9691421] BTK binds BTK inhibitors
(hasComponent)	[Complex:R-RNO-9691431] BTK:BTK inhibitors [plasma membrane]
(output)	[Reaction:R-RNO-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
(inferredTo)	[Complex:R-HSA-9606167] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane]

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