Reactome | The SHC1:SHIP1 complex is stabilized by GRB2

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The SHC1:SHIP1 complex is stabilized by GRB2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144976
displayName	The SHC1:SHIP1 complex is stabilized by GRB2
eventOf	[Pathway:R-RNO-912526] Interleukin receptor SHC signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Homo sapiens
input	4 × [EntityWithAccessionedSequence:R-RNO-74686] Grb2 [cytosol] [Complex:R-RNO-913378] Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The SHC1:SHIP1 complex is stabilized by GRB2
output	[Complex:R-RNO-913411] Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-913374] Phosphorylated SHC1 recruits SHIP - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-913424
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-912526] Interleukin receptor SHC signaling
(inferredTo)	[Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2

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