Reactome | Phosphorylation of INFAR1 by TYK2

Schema > Reaction > Entries

Phosphorylation of INFAR1 by TYK2 Show undefined attributes

catalystActivity	[CatalystActivity:10144830] protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144832
displayName	Phosphorylation of INFAR1 by TYK2
eventOf	[Pathway:R-RNO-909733] Interferon alpha/beta signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-909719] Recruitment of STAT2 to p-IFNAR1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-909730] Phosphorylation of INFAR1 by TYK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-909705] IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of INFAR1 by TYK2
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-909704] IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-909729] Activation of JAK kinases - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-909730
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-909733] Interferon alpha/beta signaling
(precedingEvent)	[Reaction:R-RNO-909719] Recruitment of STAT2 to p-IFNAR1
(inferredTo)	[Reaction:R-HSA-909730] Phosphorylation of INFAR1 by TYK2

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