Reactome | Lewis blood group biosynthesis

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Lewis blood group biosynthesis Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225273
displayName	Lewis blood group biosynthesis
eventOf	[Pathway:R-RNO-9033658] Blood group systems biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:25293] oligosaccharide biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9603989] B3GALTs transfer Gal to GlcNAc-?1,3-Gal-R to form Type 1 chain - Rattus norvegicus [Reaction:R-RNO-9603982] FUT2 transfers Fuc to LeA to form LeB - Rattus norvegicus [Reaction:R-RNO-9603984] FUT4,5,9 transfer Fuc to Type 2 chains to form LeX - Rattus norvegicus [Reaction:R-RNO-9603983] FUT2 transfers Fuc to LeX to form LeY - Rattus norvegicus [Reaction:R-RNO-9603987] ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG - Rattus norvegicus [Reaction:R-RNO-9603991] ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG - Rattus norvegicus [Reaction:R-RNO-9605600] ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG - Rattus norvegicus [Reaction:R-RNO-9605682] FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX - Rattus norvegicus [Reaction:R-RNO-9605700] B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9037629] Lewis blood group biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Lewis blood group biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9037629
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9033658] Blood group systems biosynthesis
(inferredTo)	[Pathway:R-HSA-9037629] Lewis blood group biosynthesis

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