Reactome | VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7

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VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10207095
displayName	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
eventOf	[Pathway:R-RNO-8951664] Neddylation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8956099] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 - Homo sapiens
input	[Complex:R-RNO-8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [EntityWithAccessionedSequence:R-RNO-8956071] Ubxn7 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
output	[Complex:R-RNO-8956077] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol]
precedingEvent	[Reaction:R-RNO-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex - Rattus norvegicus
regulatedBy	[NegativeRegulation:10207096] Negative regulation by 'MUL1 dimer [mitochondrial outer membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8956099
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8951664] Neddylation
(inferredTo)	[Reaction:R-HSA-8956099] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7

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