Reactome | CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85

Schema > Reaction > Entries

CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10205562
displayName	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
eventOf	[Pathway:R-RNO-182971] EGFR downregulation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8951490] CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 - Homo sapiens
input	[Complex:R-RNO-8951489] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
output	[Complex:R-RNO-8875480] CIN85:endophilin [cytosol] [Complex:R-RNO-182932] EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane]
precedingEvent	[Reaction:R-RNO-183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8951490
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-RNO-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
(inferredTo)	[Reaction:R-HSA-8951490] CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85

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