Reactome | STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor

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STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor Show undefined attributes

catalystActivity	[CatalystActivity:10205410] transmembrane receptor protein tyrosine kinase activity of IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10205412
displayName	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
eventOf	[Pathway:R-RNO-9020933] Interleukin-23 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8950269] STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-8952752] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-8952748] IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8950269
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9020933] Interleukin-23 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-8950269] STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor

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