Reactome | HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

Schema > Reaction > Entries

HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10204916
displayName	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
eventOf	[Pathway:R-RNO-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-8943040] HLTF polyubiquitinates monoubiquitinated PCNA - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8943041] HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-8855007] Hltf [nucleoplasm] [Complex:R-RNO-5651993] MonoUb:K164-PCNA homotrimer [nucleoplasm] [Complex:R-RNO-5643741] RAD18:UBE2B [nucleoplasm] [Complex:R-RNO-8943008] Ub:UBE2N:UBE2V2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
output	[Complex:R-RNO-8943053] HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8943041
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8866654] E3 ubiquitin ligases ubiquitinate target proteins
(precedingEvent)	[BlackBoxEvent:R-RNO-8943040] HLTF polyubiquitinates monoubiquitinated PCNA
(inferredTo)	[Reaction:R-HSA-8943041] HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

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